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MEDICINE: THE WEIGHT HORMONE CAN REGULATE OUR IMMUNE SYSTEM

MEDICINE: THE WEIGHT HORMONE CAN REGULATE OUR IMMUNE SYSTEM

A study carried out by the team of Immune Endocrinology of CNR from Naples, published on the Journal of Clinical Investigation, has underlined the key role played by leptine - a hormone regulating body weight - in the aetiology of serious autoimmune diseases such as experimental multiple sclerosis (experimental allergic encephalitis EAE) and autoimmune diabetes.

CNR Health 19 Jan 2003
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THE FANCONI ANAEMIA/BRCA PATHWAY

THE FANCONI ANAEMIA/BRCA PATHWAY

Fanconi anaemia (FA) is a rare genetic cancer-susceptibility syndrome that is characterized by congenital abnormalities, bone-marrow failure and cellular sensitivity to DNA crosslinking agents. Seven FA-associated genes have recently been cloned, and their products were found to interact with well-known DNA-damage-response proteins, including BRCA1, ATM and NBS1. The FA proteins could therefore be involved in the cell-cycle checkpoint and DNA-repair pathways. Recent studies implicate the FA proteins in the process of repairing chromosome defects that occur during homologous recombination, and disruption of the FA genes results in chromosome instability ”€ a common feature of many human cancers.

Redazione Health 22 Jan 2003
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